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Mitochondrial Biology Lab

Dept of Biochemistry, Indian Institute of Science, Bangalore.

2023

Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity

Abhishek Kumar, Tejashree Pradip Waingankar, Patrick D'Silva

Journal of Cell Science, 2023 Jan

2022

Double DJ-1 domain containing Arabidopsis DJ-1D is a robust macromolecule deglycase

Melvin Prasad*, Priyanka Kataria*, Sunayana Ningaraju, Radhika Buddidathi, Kondalarao Bankapalli, Swetha Chenna, Gautam Susarla, Radhika Venkatesan, Patrick D’Silva#, P. V. Shivaprasad#

New Phytologist, 2022 Jul

A journey through the gateway of polytopic inner membrane proteins: The carrier translocase machinery

Abhishek Kumar, Srujan Kumar Matta, Vigneshwaran R, Patrick D'Silva

Current Opinion in Physiology, 2022 Mar

Loss of Function of mtHsp70 Chaperone Variants Leads to Mitochondrial Dysfunction in Congenital Sideroblastic Anemia

Vinaya Vishwanathan, Patrick D'Silva

Frontiers in Cell and Developmental Biology, 2022 Feb

2021

Multiple variants of the human presequence translocase motor subunit Magmas govern the mitochondrial import

Tejashree Pradip Waingankar, Patrick D'Silva

Journal of Biological Chemistry, 2021 Dec

Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila

Prasanna Katti, Mamta Rai, Shubhi Srivastava, Patrick D'Silva, Upendra Nongthomba

Experimental Cell Research, 2021 Feb

2020

Role of conserved regions of Tim22 in the structural organization of the carrier translocase

Abhishek Kumar, Srujan Kumar Matta, Patrick D'Silva

Journal of Cell Science, 2020 Jun

Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit.

Srujan Kumar Matta, Abhishek Kumar, Patrick D’Silva

Molecular Biology of the Cell, 2020 May

Redox-dependent Regulation of Mitochondrial Dynamics by DJ-1 Paralogs in Saccharomyces Cerevisiae

Kondalarao Bankapalli, Vinaya Vishwanathan, Gautam Susarla, Ningaraju Sunayana, SreeDivya Saladi, Divya Peethambaram, Patrick D'Silva

Redox Biology, 2020 Feb

Evolving Paradigms on the Interplay of Mitochondrial Hsp70 Chaperone System in Cell Survival and Senescence

Shubhi Srivastava, Vinaya Vishwanathan, Abhijit Birje, Devanjan Sinha, Patrick D'Silva

Critical Reviews in Biochemistry and Molecular Biology, 2020 Jan

2019

A manganese oxide nanozyme prevents the oxidative damage of biomolecules without affecting the endogenous antioxidant system

Namrata Singh, Mohammed Azharuddin Savanur, Shubhi Srivastava, Patrick D'Silva, Govindasamy Mugesh

Nanoscale, 2019 Feb

2017

Redox Modulatory Mn3O4 Nanozyme with Multi-enzyme Activity Provides Efficient Cytoprotection to Human Cells in Parkinson's Disease Model.

Govindasamy Mugesh, Namrata Singh, Mohammed Azharuddin Savanur, Shubhi Srivastava, Patrick D'Silva

Angew Chem Int Ed Engl, 2017 Sept

Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells.

Shubhi Srivastava, Mohammed Azharuddin Savanur, Devanjan Sinha, Abhijit Birje, Vigneshwaran Renganathan, Prasenjit Prasad Saha, Patrick D'Silva*

J Biol Chem, 2017 Aug

Iron-Sulfur Protein Assembly in Human Cells

Prasenjit Prasad Saha, Vinaya Vishwanathan, Kondalarao Bankapalli, Patrick D'Silva*

Rev Physiol Biochem Pharmacol, 2017 Aug

Methylglyoxal detoxification by a DJ-1 family protein provides dual abiotic and biotic stress tolerance in transgenic plants.

Prasad Melvin, Kondalarao Bankapalli, Patrick D'Silva, P. V. Shivaprasad

Plant Mol Biol, 2017 Jul

Role of Tim17 transmembrane regions in regulating the architecture of presequence translocase and mtDNA stability.

Srujan Kumar Matta, Gautam Pareek, Kondalarao Bankapalli, Anjaneya O, Patrick D'Silva*

Mol Cell Biol, 2017 Mar

2016

Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase

Devanjan Sinha, Shubhi Srivastava, Patrick D'Silva*

J Biol Chem, 2016 Aug

2015

Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein is critical for oxidative stress resistance in Saccharomyces cerevisiae

Kondalarao Bankapalli, SreeDivya Saladi, Sahezeel S Awadia, Arvind Vittal Goswami, Madhuja Samaddar, Patrick D'Silva*

J Biol Chem, 2015 Oct

Mapping key residues of ISD11 critical for NFS1-ISD11 subcomplex stability: Implications in the development of mitochondrial disorder, COXPD19

Prasenjit Prasad Saha, Shubhi Srivastava, Praveen Kumar S.K, Devanjan Sinha, Patrick D'Silva*

J Biol Chem, 2015 Oct

A Pd8 Tetrafacial Molecular Barrel as Carrier for Water Insoluble Fluorophore.

Bijan Roy, Aloke kumar ghosh, Shubhi Srivastava, Patrick D’ Silva, Partha Sarathi Mukherjee

J. Am. Chem. Soc, 2015 Sept

Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.

Bhowmick D#, Srivastava S#, D'Silva P*, Mugesh G*.

Angew Chem Int Ed, 2015 Jul

2014

An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires.

Amit A. Vernekar#, D Sinha#, S Srivastava, P U. Paramasivam, P D’Silva*, G Mugesh*

Nat. Communications, 2014 Nov

Magmas functions as a ROS regulator and provides cytoprotection against oxidative stress-mediated damages.

S Srivastava, D Sinha, P P Saha, H Marthala, P D'Silva*

Nat. Cell Death and Disease, 2014 Aug

Role of the loop L4,5 in allosteric regulation in mtHsp70s: Revealing in vivo significance of domain communication and its implications in protein translocation.

Madhuja Samaddar, Arvind Vittal Goswami*, Jaya Purushotham, Pushpa Hegde#, Patrick D’Silva‡

Mol. Biol. Cell, 2014 May

Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15

D Sinha, P D'Silva*

Nat. Cell Death and Disease, 2014 Mar

Unraveling the intricate organization of mammalian mitochondrial presequence translocases: Existence of multiple translocases for maintenance of mitochondrial function

Devanjan Sinha, Shubhi Srivastava, Lekshmi Krishna, Patrick D’Silva*

Mol Cell Biol, 2014 Mar

The Presence of Multiple Cellular Defects Associated with a Novel G50E ISCU Mutation leads to Development of Mitochondrial Myopathy

Prasenjit Prasad Saha, Praveen Kumar S. K, Shubhi Srivastava, Devanjan Sinha, Gautam Pareek, Patrick D'Silva*

J Biol Chem, 2014 Feb

2013

Molecular insights revealing interaction of Tim23 and channel subunits of presequence-translocase

Gautam Pareek, Vivekanandhan Krishnamoorthy, Patrick D′ Silva*

Mol Cell Biol, 2013 Dec

Rapid Characterization of Hydrogen Exchange in Proteins

Anushikha Thakur#, Dr. Kousik Chandra#, Abhinav Dubey, Dr. Patrick D'Silva*, Dr. Hanudatta S.Atreya*

Angew Chem Int Ed Engl, 2013 Feb

2012

HSPIR: A manually annotated Heat Shock Protein Information Resource.

Ratheesh Kumar R, Nagarajan N.S, Arunraj S.P, Devanjan Sinha, Vinoth Babu Veedin Rajan, Vinoth Kumar Esthaki, Patrick D’Silva*

Bioinformatics, 2012 Nov

Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease

Arvind Vittal Goswami, Madhuja Samaddar, Devanjan Sinha, Jaya Purushotham, Patrick D'Silva*

Hum. Mol. Genet, 2012

Structure and Mechanistic Insights into Novel Iron-mediated Moonlighting Functions of Human J-protein Cochaperone, Dph4.

Anushikha Thakur, Balasubramanyam Chitoor, Arvind V. Goswami, Gautam Pareek, Hanudatta S. Atreya, Patrick D'Silva*

J. Biol. Chem, 2012

2011

Primary Sequence That Determines the Functional Overlap between Mitochondrial Heat Shock Protein 70 Ssc1 and Ssc3 of Saccharomyces cerevisiae

Gautam Pareek, Madhuja Samaddar, Patrick D'Silva*

J. Biol. Chem, 2011

Amino acid selective unlabeling for sequence specific resonance assignments in proteins.

B. Krishnarjuna#, Garima Jaipuria, Anushikha Thakur#, Patrick D'Silva*, Hanudatta S. Atreya*

J Biomol NMR, 49, 2011

2010

High-resolution methyl edited GFT NMR experiments for protein resonance assignments and structure determination.

Garima Jaipuria#, Anushikha Thakur#, Patrick D'Silva*, Hanudatta S. Atreya*

J Biomol NMR, 48, 2010

Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components.

Arvind Vittal Goswami, Balasubramanyam Chittoor, Patrick D'Silva*

J. Biol. Chem, 285, 2010

Role of Magmas in protein transport and human mitochondrial biogenesis.

Devanjan Sinha, Neha Joshi, Balasubramanyam Chittoor, Priyanka Samji, Patrick D' Silva*

Hum. Mol. Genet, 19, 2010

2009

Arabidopsis thaliana, J-class heat shock proteins: cellular stress sensors.

Vinoth Babu V. Rajan, Patrick D' Silva*

Funct Integr Genomics, 9, 2009

2003-2008

Interaction of the J-Protein Heterodimer Pam18/Pam16 of the Mitochondrial Import Motor with the Translocon of the Inner Membrane.

Patrick R. D' Silva, Brenda Schilke, Masaya Hayashi, Elizabeth A. Craig.

Mol. Biol. Cell, 19, 2008

Compensation for a Defective Interaction of the Hsp70 Ssq1 with the Mitochondrial Fe-S Cluster Scaffold Isu*

Helena Knieszner, Brenda Schilke, Rafal Dutkiewicz, Patrick D'Silva, Sara Cheng, Maikke Ohlson, Elizabeth A. Craig, Jaroslaw Marszalek

J Biol Chem, 32, 2006

Evolution of Mitochondrial Chaperones Utilized in Fe-S Cluster Biogenesis.

Brenda Schilke, Barry Williams, Helena Knieszner, Sebastian Pukszta, Patrick D'Silva, Elizabeth A. Craig, Jaroslaw Marszalek

Curr Biol, 16, 2006

An Essential Connection: Link between Hsp70's Domains At Last.

Patrick D' Silva, Jaroslaw Marszalek, Elizabeth A. Craig

Mol. Cell, 20, 2005

Role of Pam16's Degenerate J-Domain in Protein Import Across the Mitochondrial Inner Membrane.

Patrick R. D' Silva, Brenda Schilke, William Walter, Elizabeth A. Craig

Pro. Natl. Acad. Sci. (USA), 102, 2005

Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane.

Patrick R. D' Silva, Brenda Schilke, William Walter, Elizabeth A. Craig.

Nat. Struct. Mol. Biol, 11, 2004

J-protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix.

Patrick D. D' Silva, Brenda Schilke, William Walter, Amy Andrew, Elizabeth A. Craig.

Proc. Natl. Acad. Sci. (USA), 100, 2003

Regulated cycling of mitochondrial Hsp70 at the protein import channel.

Qinglian Liu, Patrick D' Silva, William Walter, Jaroslaw Marszalek, Elizabeth A. Craig

Science, 2003