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MOLECULAR CHAPERONE LAB

Dept of Biochemistry, Indian Institute of Science, Bangalore.

List of Publications by Year

Year 2017



Govindasamy Mugesh, Namrata Singh, Mohammed Azharuddin Savanur, Shubhi Srivastava and Patrick D'Silva
Redox Modulatory Mn3O4 Nanozyme with Multi-enzyme Activity Provides Efficient Cytoprotection to Human Cells in Parkinson's Disease Model.
Angew Chem Int Ed Engl. 2017 September 18.new



Shubhi Srivastava, Mohammed Azharuddin Savanur, Devanjan Sinha, Abhijit Birje, Vigneshwaran Renganathan, Prasenjit Prasad Saha and Patrick D'Silva*
Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells.
J Biol Chem. 2017 August 28.new



Prasenjit Prasad Saha, Vinaya Vishwanathan, Kondalarao Bankapalli and Patrick D'Silva*
Iron-Sulfur Protein Assembly in Human Cells
Rev Physiol Biochem Pharmacol. 2017 August 22.new



Prasad Melvin, Kondalarao Bankapalli, Patrick D'Silva and P. V. Shivaprasad
Methylglyoxal detoxification by a DJ-1 family protein provides dual abiotic and biotic stress tolerance in transgenic plants.
Plant Mol Biol. 2017 July 1.new



Srujan Kumar Matta, Gautam Pareek, Kondalarao Bankapalli, Anjaneya O and Patrick D'Silva*
Role of Tim17 transmembrane regions in regulating the architecture of presequence translocase and mtDNA stability.
Mol Cell Biol. 2017 March 1.new


Year 2016



Devanjan Sinha, Shubhi Srivastava and Patrick D'Silva*
Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase
J Biol Chem. 2016 August 12.new


Year 2015



Kondalarao Bankapalli, SreeDivya Saladi, Sahezeel S Awadia, Arvind Vittal Goswami, Madhuja Samaddar and Patrick D'Silva*
Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein is critical for oxidative stress resistance in Saccharomyces cerevisiae
J Biol Chem. 2015 October 30.new   Bangalore Mirror   IISc Logo   IISc Logo


Prasenjit Prasad Saha, Shubhi Srivastava, Praveen Kumar S.K, Devanjan Sinha and Patrick D'Silva*
Mapping key residues of ISD11 critical for NFS1-ISD11 subcomplex stability: Implications in the development of mitochondrial disorder, COXPD19
J Biol Chem. 2015 October 23.new


Bijan Roy, aloke kumar ghosh, Shubhi Srivastava, Patrick D’ Silva, and Partha Sarathi Mukherjee
A Pd8 Tetrafacial Molecular Barrel as Carrier for Water Insoluble Fluorophore.
J. Am. Chem. Soc. 2015 September 23.new


Bhowmick D#, Srivastava S#, D'Silva P*, Mugesh G*. ( # First Co-Author, * Equal Corresponding Senior Author)
Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.
Angew Chem Int Ed. 2015 July.    new   new   IISc Logo

Note:   Highlights  in   Angew Chem Int Ed. July 2015,  by   Prof. Dr. Thomas Wirth,   Cardiff University, UK.


Year 2014


Amit A. Vernekar#, D Sinha#, S Srivastava, P U. Paramasivam, P D’Silva* & G Mugesh*. ( # First Co-Author, * Equal Corresponding Senior Author)
An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires.
Nat. Communications, 21 November 2014.    The Hindu logo   The new indian express logo   TOI logo   NDTV Logo   Economic times Logo   deccan Herald Logo   naidunia Logo   IISc Logo


S Srivastava, D Sinha, P P Saha, H Marthala and P D'Silva*
Magmas functions as a ROS regulator and provides cytoprotection against oxidative stress-mediated damages.
Nat. Cell Death and Disease, 28 August 2014.    The new indian express logo   IISc Logo


Madhuja Samaddar, Arvind Vittal Goswami*, Jaya Purushotham, Pushpa Hegde# and Patrick D’Silva‡
Role of the loop L4,5 in allosteric regulation in mtHsp70s: Revealing in vivo significance of domain communication and its implications in protein translocation.
Mol. Biol. Cell, May 14, 2014.


D Sinha and P D'Silva*.
Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15
Nat. Cell Death and Disease, 6 March 2014.



Devanjan Sinha, Shubhi Srivastava, Lekshmi Krishna and Patrick D’Silva*.
Unraveling the intricate organization of mammalian mitochondrial presequence translocases: Existence of multiple translocases for maintenance of mitochondrial function
Mol Cell Biol. 2014 Mar 17.



Prasenjit Prasad Saha, Praveen Kumar S. K, Shubhi Srivastava, Devanjan Sinha, Gautam Pareek and Patrick D'Silva*.
The Presence of Multiple Cellular Defects Associated with a Novel G50E ISCU Mutation leads to Development of Mitochondrial Myopathy
J Biol Chem. 2014 Feb 26.

Year 2013


Gautam Pareek, Vivekanandhan Krishnamoorthy and Patrick D′ Silva*.
Molecular insights revealing interaction of Tim23 and channel subunits of presequence-translocase
Mol Cell Biol. 2013 Dec.



Anushikha Thakur#, Dr. Kousik Chandra#, Abhinav Dubey, Dr. Patrick D'Silva*, Prof. Hanudatta S.Atreya*. ( # First Co-Author, * Equal Corresponding Senior Author)
Rapid Characterization of Hydrogen Exchange in Proteins
Angew Chem Int Ed Engl. 2013 Feb 25.

Year 2012


Ratheesh Kumar R, Nagarajan N.S, Arunraj S.P, Devanjan Sinha, Vinoth Babu Veedin Rajan, Vinoth Kumar Esthaki, and Patrick D’Silva*.
HSPIR: A manually annotated Heat Shock Protein Information Resource.
Bioinformatics. Nov 1, 2012.



Arvind Vittal Goswami, Madhuja Samaddar, Devanjan Sinha, Jaya Purushotham, and Patrick D'Silva*.
Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease
Hum. Mol. Genet, 2012.



Anushikha Thakur, Balasubramanyam Chitoor, Arvind V. Goswami, Gautam Pareek, Hanudatta S. Atreya, and Patrick D'Silva*.
Structure and Mechanistic Insights into Novel Iron-mediated Moonlighting Functions of Human J-protein Cochaperone, Dph4.
J. Biol. Chem, 2012.

Year 2011


Gautam Pareek, Madhuja Samaddar and Patrick D'Silva*.
Primary Sequence That Determines the Functional Overlap between Mitochondrial Heat Shock Protein 70 Ssc1 and Ssc3 of Saccharomyces cerevisiae.
J. Biol. Chem, 2011.



B. Krishnarjuna#, Garima Jaipuria, Anushikha Thakur#, Patrick D'Silva* & Hanudatta S. Atreya*. ( # First Co-Author, * Equal Corresponding Senior Author)
Amino acid selective unlabeling for sequence specific resonance assignments in proteins.
J Biomol NMR. 49, 2011.

Year 2010


Garima Jaipuria#, Anushikha Thakur#, Patrick D'Silva* & Hanudatta S. Atreya*. ( # First Co-Author, * Equal Corresponding Senior Author)
High-resolution methyl edited GFT NMR experiments for protein resonance assignments and structure determination.
J Biomol NMR. 48, 2010.



Arvind Vittal Goswami, Balasubramanyam Chittoor, Patrick D'Silva*.
Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components.
J. Biol. Chem. 285, 2010.



Devanjan Sinha, Neha Joshi, Balasubramanyam Chittoor, Priyanka Samji, Patrick D' Silva*.
Role of Magmas in protein transport and human mitochondrial biogenesis.
Hum. Mol. Genet. 19, 2010.

Year 2009


Vinoth Babu V. Rajan, Patrick D' Silva*.
Arabidopsis thaliana, J-class heat shock proteins: cellular stress sensors."
Funct Integr Genomics. 9: 2009.


Year 2003-2008



Patrick R. D' Silva, Brenda Schilke, Masaya Hayashi and Elizabeth A. Craig.
"Interaction of the J-Protein Heterodimer Pam18/Pam16 of the Mitochondrial Import Motor with the Translocon of the Inner Membrane."
Mol. Biol. Cell. 19, 2008.



Helena Knieszner, Brenda Schilke, Rafal Dutkiewicz, Patrick D'Silva, Sara Cheng,Maikke Ohlson, Elizabeth A. Craig, and Jaroslaw Marszalek.
"Compensation for a Defective Interaction of the Hsp70 Ssq1 with the Mitochondrial Fe-S Cluster Scaffold Isu*."
J Biol Chem. 32, 2006.



Brenda Schilke, Barry Williams, Helena Knieszner, Sebastian Pukszta, Patrick D'Silva, Elizabeth A. Craig and Jaroslaw Marszalek.
"Evolution of Mitochondrial Chaperones Utilized in Fe-S Cluster Biogenesis."
Curr Biol. 16, 2006.



Patrick D' Silva, Jaroslaw Marszalek and Elizabeth A. Craig.
"An Essential Connection: Link between Hsp70's Domains At Last."
Mol. Cell. 20, 2005.



Patrick R. D' Silva, Brenda Schilke, William Walter and Elizabeth A. Craig.
"Role of Pam16's Degenerate J-Domain in Protein Import Across the Mitochondrial Inner Membrane."
Pro. Natl. Acad. Sci. (USA). 102, 2005.



Patrick R. D' Silva, Brenda Schilke, William Walter and Elizabeth A. Craig.
"Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane."
Nat. Struct. Mol. Biol. 11, 2004.



Patrick D. D' Silva, Brenda Schilke, William Walter, Amy Andrew and Elizabeth A. Craig.
"J-protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix."
Proc. Natl. Acad. Sci. (USA). 100, 2003.



Qinglian Liu, Patrick D' Silva, William Walter, Jaroslaw Marszalek, Elizabeth A. Craig.
"Regulated cycling of mitochondrial Hsp70 at the protein import channel."
Science. 2003.