Mitochondrial Biology Lab

Amit A. Vernekar^#, D Sinha^#, S Srivastava, P U. Paramasivam, P D’Silva^* & G Mugesh^*. ( ^# First Co-Author, * Equal Corresponding Senior Author)
An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires.
Nat. Communications, 21 November 2014.                         

S Srivastava, D Sinha, P P Saha, H Marthala and P D'Silva^*
Magmas functions as a ROS regulator and provides cytoprotection against oxidative stress-mediated damages.
Nat. Cell Death and Disease, 28 August 2014.       

Madhuja Samaddar, Arvind Vittal Goswami^*, Jaya Purushotham, Pushpa Hegde^# and Patrick D’Silva‡
Role of the loop L4,5 in allosteric regulation in mtHsp70s: Revealing in vivo significance of domain communication and its implications in protein translocation.
Mol. Biol. Cell, May 14, 2014.

D Sinha and P D'Silva^*.
Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15
Nat. Cell Death and Disease, 6 March 2014.

Devanjan Sinha, Shubhi Srivastava, Lekshmi Krishna and Patrick D’Silva^*.
Unraveling the intricate organization of mammalian mitochondrial presequence translocases: Existence of multiple translocases for maintenance of mitochondrial function
Mol Cell Biol. 2014 Mar 17.

Prasenjit Prasad Saha, Praveen Kumar S. K, Shubhi Srivastava, Devanjan Sinha, Gautam Pareek and Patrick D'Silva^*.
The Presence of Multiple Cellular Defects Associated with a Novel G50E ISCU Mutation leads to Development of Mitochondrial Myopathy
J Biol Chem. 2014 Feb 26.

Gautam Pareek, Vivekanandhan Krishnamoorthy and Patrick D′ Silva^*.
Molecular insights revealing interaction of Tim23 and channel subunits of presequence-translocase
Mol Cell Biol. 2013 Dec.

Anushikha Thakur^#, Dr. Kousik Chandra^#, Abhinav Dubey, Dr. Patrick D'Silva^*, Prof. Hanudatta S.Atreya^*. ( ^# First Co-Author, * Equal Corresponding Senior Author)
Rapid Characterization of Hydrogen Exchange in Proteins
Angew Chem Int Ed Engl. 2013 Feb 25.

Ratheesh Kumar R, Nagarajan N.S, Arunraj S.P, Devanjan Sinha, Vinoth Babu Veedin Rajan, Vinoth Kumar Esthaki, and Patrick D’Silva^*.
HSPIR: A manually annotated Heat Shock Protein Information Resource.
Bioinformatics. Nov 1, 2012.

Arvind Vittal Goswami, Madhuja Samaddar, Devanjan Sinha, Jaya Purushotham, and Patrick D'Silva^*.
Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease
Hum. Mol. Genet, 2012.

Anushikha Thakur, Balasubramanyam Chitoor, Arvind V. Goswami, Gautam Pareek, Hanudatta S. Atreya, and Patrick D'Silva^*.
Structure and Mechanistic Insights into Novel Iron-mediated Moonlighting Functions of Human J-protein Cochaperone, Dph4.
J. Biol. Chem, 2012.

Gautam Pareek, Madhuja Samaddar and Patrick D'Silva^*.
Primary Sequence That Determines the Functional Overlap between Mitochondrial Heat Shock Protein 70 Ssc1 and Ssc3 of Saccharomyces cerevisiae.
J. Biol. Chem, 2011.

B. Krishnarjuna^#, Garima Jaipuria, Anushikha Thakur^#, Patrick D'Silva^* & Hanudatta S. Atreya^*. ( ^# First Co-Author, * Equal Corresponding Senior Author)
Amino acid selective unlabeling for sequence specific resonance assignments in proteins.
J Biomol NMR. 49, 2011.

Garima Jaipuria^#, Anushikha Thakur^#, Patrick D'Silva^* & Hanudatta S. Atreya^*. ( ^# First Co-Author, * Equal Corresponding Senior Author)
High-resolution methyl edited GFT NMR experiments for protein resonance assignments and structure determination.
J Biomol NMR. 48, 2010.

Arvind Vittal Goswami, Balasubramanyam Chittoor, Patrick D'Silva^*.
Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components.
J. Biol. Chem. 285, 2010.

Devanjan Sinha, Neha Joshi, Balasubramanyam Chittoor, Priyanka Samji, Patrick D' Silva^*.
Role of Magmas in protein transport and human mitochondrial biogenesis.
Hum. Mol. Genet. 19, 2010.

Vinoth Babu V. Rajan, Patrick D' Silva^*.
Arabidopsis thaliana, J-class heat shock proteins: cellular stress sensors."
Funct Integr Genomics. 9: 2009.

Patrick R. D' Silva, Brenda Schilke, Masaya Hayashi and Elizabeth A. Craig.
"Interaction of the J-Protein Heterodimer Pam18/Pam16 of the Mitochondrial Import Motor with the Translocon of the Inner Membrane."
Mol. Biol. Cell. 19, 2008.

Helena Knieszner, Brenda Schilke, Rafal Dutkiewicz, Patrick D'Silva, Sara Cheng,Maikke Ohlson, Elizabeth A. Craig, and Jaroslaw Marszalek.
"Compensation for a Defective Interaction of the Hsp70 Ssq1 with the Mitochondrial Fe-S Cluster Scaffold Isu^*."
J Biol Chem. 32, 2006.

Brenda Schilke, Barry Williams, Helena Knieszner, Sebastian Pukszta, Patrick D'Silva, Elizabeth A. Craig and Jaroslaw Marszalek.
"Evolution of Mitochondrial Chaperones Utilized in Fe-S Cluster Biogenesis."
Curr Biol. 16, 2006.

Patrick D' Silva, Jaroslaw Marszalek and Elizabeth A. Craig.
"An Essential Connection: Link between Hsp70's Domains At Last."
Mol. Cell. 20, 2005.

Patrick R. D' Silva, Brenda Schilke, William Walter and Elizabeth A. Craig.
"Role of Pam16's Degenerate J-Domain in Protein Import Across the Mitochondrial Inner Membrane."
Pro. Natl. Acad. Sci. (USA). 102, 2005.

Patrick R. D' Silva, Brenda Schilke, William Walter and Elizabeth A. Craig.
"Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane."
Nat. Struct. Mol. Biol. 11, 2004.

Patrick D. D' Silva, Brenda Schilke, William Walter, Amy Andrew and Elizabeth A. Craig.
"J-protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix."
Proc. Natl. Acad. Sci. (USA). 100, 2003.

Qinglian Liu, Patrick D' Silva, William Walter, Jaroslaw Marszalek, Elizabeth A. Craig.
"Regulated cycling of mitochondrial Hsp70 at the protein import channel."
Science. 2003.