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MOLECULAR CHAPERONE LAB

Dept of Biochemistry, Indian Institute of Science, Bangalore.

Principal Investigator

Patrick D' Silva

Prof. Patrick D' Silva
Associate Professor

Post Doctoral Fellows

devanjan

Dr. Retheesh S T

UGC Dr.D S Kothari Fellow

divyap

Dr. Divya P

UGC Dr.D S Kothari Fellow

azhar

Dr. Mohammed Azharuddin Savanur

Post Doctoral Fellow

sunayana

Dr. Sunayana Gowda

SERB- National Postdoctoral Fellow

PhD Students

kondalarao

Kondalarao B

PhD Student

abhijit

Abhijit Birje

PhD Student

srujan

Srujan Kumar Matta

PhD Student

vinaya

Vinaya Vishwanathan

PhD Student

Abhishek

Abhishek Kumar

PhD Student

ena

Ena Dhaddha

PhD Student

gayatri

Gayatri Namala

PhD Student

tejashree

Tejashree Waingankar

PhD Student

sanjay

Sanjay Prasad

PhD Student

gautamsusarla

Gautam Susarla

Integrated PhD Student

priyanka

Priyanka Kataria

Integrated PhD Student

Research Fellows

vigneshwaran

Vigneshwaran R

Senior Research Fellow

saravana

Saravana Raja R

Project Assistant

Alumnus Students

Name

PhD

Position

Locality

------- ------ ------------ ------------

Dr. Shubhi Srivastava

2017 -- --

Dr. Prasenjit Prasad Saha

2015 Post Doctoral Fellow Dr. Stanely L Hazen's Lab, Cleveland Clinic, Cleveland, OH

Dr. Madhuja Samaddar

2015 Postdoctoral Researcher Cynthia Kenyon's Lab, Calico Labs, South San Francisco, CA

Dr. Gautam Pareek

2014 Post Doctoral Fellow Prof. Dan Gottschling Lab, FHCRC, Seattle, USA.

Dr. Devanjan Sinha

2014 Assistant Professor Institute of Science, Banaras Hindu University, Uttar Pradesh, India.

Dr. Arvind Vittal Goswami

2014 Post Doctoral Fellow Prof. Gerald S Shadel Lab, Yale University, USA.

Dr. Anushikha Thakur

2012 Assistant Scientific Manager Biocon, Bangalore, India.

Alumnus Project Assistants & Post Doctoral Fellow

Name

Position

Locality

------- ------------ ------------

Saladi Sreedivya

PhD Student Kaiserslautern University of Technology, Kaiserslautern, Germany

Dr. Anjaneya Oblesha

Assistant Professor Sri Lakshmi Venkatesh Desai College, Raichur

Arunraj S.P

PhD Student Max Planck Institute for Evolutionary Biology, Plon, Germany

Dr. Praveen Kumar.S.K

Asst. Professor Karnatak University, Dharwad, Karnataka

Pushpa Hegde

PhD Student INSERM, Centre de Recherche des Cordeliers, Paris, France

Ambika Nadkarni

PhD Student University of Illinois, Urbana-Champaign, USA.

Vinoth Babu Veedin Rajan

PhD Student Max F.Perutz Laboratories,Vienna Biocenter GmbH.

Balasubramanyam C

PhD Student Umea university, Sweden.

Akhil Sarogi

M.Tech Student IIT, Kharagpur

Saroj Yadav

PhD Student Monash Research academy, IIT, Mumbai.

Shanthi

SRF-ICMR Periyar University,Salem.

Nagarajan N.S

Associate Developer Coextrix Technologies,Bangalore.

Ratheesh Kumar.R

API Developer-Php Sixth Energy Technologies pvt.ltd, Bangalore.

Sahezeel Awadia

PhD Student University of Toledo, Ohio, USA.

Ajeet Singh

PhD Student IIT, Kharagpur, India

Vivekanandhan Krishnamoorthy

Research Associate DuPont India, Hyderabad, India.

Dr. Priyanka Samji

Associate Professor MLACW, Bangalore, India.

Devipriya Rajkumar

PhD Student Institute of Toxicology and Genetics, Lucknow, India

Neha Joshi

- -

Lekshmi Krishna

- -

Prashanna Kumar R.S

- -

Purushotham Jaya

Transgenic Assistant National Mouse Transgenic Facility, NCBS, Bangalore.

Vinoth Kumar E

Web Developer TROPPUS Web Services, Bangalore, India

Lakshmi Prasanna

- Marseille, France

Dr. Retheesh S T

UGC Dr.D S Kothari Fellow
ratheesh

Summary of Research


Dr. Divya P

UGC Dr.D S Kothari Fellow
divyap

Credentials

M.Sc in Biotechnology, Kannur University, Kerala.
PhD in Biotechnology, Central Food Technological Research Institute, Mysore.
Present Status: Dr. D S Kothari Post Doctoral Fellow, IISc, Bangalore

Fellowships

UGC Dr. D S Kothari Post Doctoral Fellowship
Research Fellowship from CSIR - JRF and SRF

Summary of Research


Dr. Mohammed Azharuddin Savanur

Post Doctoral Fellow
azhar

Credentials

yet to update

Fellowships

yet to update

Summary of Research


Dr. Sunayana Gowda

SERB- National Postdoctoral Fellow
sunayana

Credentials

M.Sc In Biotechnology, Bangalore University
Ph.D in Biotechnology, University of Mysore, Manasagangotri, Mysore
Present Status: SERB- National Postdoctoral Fellow, IISc, Bangalore

Fellowships

SERB- National Postdoctoral Fellowship
Research Fellowship from DBT sponsored project -JRF and ICMR- SRF

Summary of Research


Kondalarao B

PhD Student
kondalarao

Credentials

M.Sc in Biochemistry, Andhra University, Visakhapatnam.
Present Status: Ph.D in Biochemistry, IISc-Bangalore.

Fellowships

Research fellowship from CSIR-JRF and SRF

Summary of Research



Oxidative stress is a result of inefficient ROS scavenging mechanisms in cellular system. In addition to normal cellular aging, oxidative stress has been implicated in neurological disorders like Alzheimer's, Parkinson’s and Huntington’s disease and also in multiple cancers. In addition, glyoxals, which are normally generated as an intermediate compound in the glycolytic pathway, are known to increase the effect of ROS by inhibiting glutathione reductase, a key enzyme which regulates levels of reduced glutathione inside the cell. To decrease the risk of glyoxals, cells across many species have glyoxalase system comprising glyoxalases, which converts toxic glyoxals into non-toxic lactic acid. Apart from its direct role in ROS scavenging in its reduced state, Glutathione additionally also plays a critical role by acting as a co-factor for glyoxalase-I and glyoxalase-II to combat with toxicity of the glyoxals.
Heat shock proteins (HSPs) are known to play a crucial role in cell survival under environmental stress conditions such as heat stress, osmotic stress, nutritional stress and oxidative stress. Molecular chaperones play a pivotal role in executing proper protein folding thus enabling maintenance of protein homeostasis, in turn ensuring proper functioning of the cell. Human P31, a redox sensor protein in mammals is known to be involved in protection of cells from oxidative stress in substantia nigra cells of dopaminergic neurons. Strikingly, yeast has four paralogs belong to the Human P31 family which are called as P31 minifamily genes. However, the molecular mechanisms underlying of these family proteins in yeast are unclear. Using biochemical and genetical approaches we are currently dissecting out the functional significance of these P31 minifamily proteins taking Saccharomyces cerevisiae as a model organism.



Publications


Kondalarao Bankapalli, SreeDivya Saladi, Sahezeel S Awadia, Arvind Vittal Goswami, Madhuja Samaddar and Patrick D'Silva*
Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein is critical for oxidative stress resistance in Saccharomyces cerevisiae
J Biol Chem. 2015 September 14.

Abhijit Birje

PhD Student
abhijit

Credentials


Present Status: PhD in Biological Sciences, IISc, Bangalore.

Fellowships

IISc PhD Fellowship.

Summary of Research


yet to update....

Hobbies



Photography

Srujan Kumar Matta

PhD Student
srujan

Credentials

B.Sc in Biotechnology, Kakatiya University, Warangal.
M.Sc in Biochemistry, Osmania University,Hyderabad.
Present Status: Ph.D in Biochemistry, IISc-Bangalore.

Fellowships

IISc PhD fellowship.

Summary of Research


Mitochondrion is an endosymbiotic organelle and contains its own DNA, RNA and a complete transcription and translation machinery, which allows them to translate some of their own proteins. Being highly integrated into the metabolism, mitochondria have transferred the vast majority of their genes into the nuclear genome. Therefore, only a handful of proteins (~ 1%) are encoded by the mitochondrial genome including the components of the oxidative phosphorylation machinery (OXPHOS). Several hundreds of proteins residing in various mitochondrial compartments are encoded by the nuclear genome and are subsequently translocated into the correct mitochondrial sub-compartment. This raises several fundamental questions about how these proteins are translocated across the membranes and assembled into their functional forms.

Almost 60% of the proteins that are targeted to mitochondria are synthesized on cytosolic ribosomes with N terminal presequence and are destined to matrix through specialized protein translocation machinery located in the inner membrane of mitochondria known as presequence-translocase or TIM23 complex. Presequence-translocase consists of central channel-forming components mainly constituted by the Tim23 protein together with Tim17, which maintains the integrity of the translocation pore. Other proteins of the complex include Tim21, Tim50, PAM16, PAM17, PAM18, TAM41 and mtHSP70 along with its co-chaperone mge1.

Tim23p is the central channel forming component of presequence-translocase which acts as receptor for preproteins and largely constitutes to the preproteins-conducting passageway. Previous findings from our lab has provided insights into the functions of different segments of TIM23p in interaction with preproteins as well as other partner proteins of the complex at molecular and biochemical level. Tim17p shares similar transmembrane topology with Tim23 and it’s been hypothesized that Tim17p is required for maintaining the architecture of the presequence-translocase, but how Tim17p modulates the architecture of the complex at molecular level is not completely understood. So my study is focused on providing molecular insights into the role of Tim17p in regulating the channel activity of Tim23p as well as its interaction with different subunits of the complex by utilizing various genetic and biochemical approaches using Saccharomyces cerevisiae as a model organism.

Hobbies


cricket, badminton.

Vinaya Vishwanathan

PhD Student
vinaya

Credentials


Present Status: PhD in Biological Sciences, IISc, Bangalore.

Fellowships

IISc PhD Fellowship.

Summary of Research


yet to update....

Hobbies



Abhishek Kumar

PhD Student
abhishek

Credentials


B.Sc. Honours in Biotechnology, Science College, Patna.
M.Sc. in Genomics, Madurai Kamaraj University, Madurai.
Present Status: PhD in Biological Sciences, IISc, Bangalore.

Fellowships

CSIR-JRF.

Summary of Research


yet to update....

Hobbies



Ena Dhaddha

PhD Student
ena

Credentials


Present Status: PhD in Biological Sciences, IISc, Bangalore.

Fellowships

yet to update

Summary of Research


yet to update....

Hobbies



M Gayatri Devi Namala

PhD Student
ena

Credentials


B.Sc in Biochemistry, Andhra University.
M.Sc in Microbiology, Andhra University.
Present Status: PhD in Biological Sciences, IISc, Bangalore.

Fellowships

CSIR-NET

Summary of Research


yet to update....

Hobbies



Tejashree Waingankar

PhD Student
tejashree

Credentials

M.Sc in Biotechnology, Savitribai Phule Pune University, Pune.
Present Status: Ph.D in Biological Sciences, IISc-Bangalore.

Fellowships

Research fellowship CSIR-JRF

Summary of Research



Yet to update



Sanjay Prasad

PhD Student
sanjay

Credentials

B.Pharma.: Muzaffarpur Institute of Technology, Bihar University, Muzaffarpur
M.Tech in Biotechnology, Anna University, Chennai
Present Status: Senior Scientific Officer, Dept. of IPC, IISc, Bangalore

Fellowships


Yet to update!

Summary of Research


yet to update....

Hobbies



Badminton

Gautam Susarla

Integrated PhD Student
gautamsusarla

Credentials

B.Sc Life Sciences, Osmania University, Hyderabad, Telangana
Present Status: Integrated PhD in Biological Sciences, IISc,Bangalore

Fellowships



Summary of Research


yet to update....

Hobbies


Playing Football
Bike Riding
Swimming
Wildlife Trekking

Priyanka Kataria

Integrated PhD Student
priyanka

Credentials


Yet to update!

Fellowships



Summary of Research


yet to update....

Hobbies



Arunraj S.P.

Junior Research Fellow
name

Credentials


B.Sc in Biochemistry from University of Madras, Chennai
M.Sc in Bioinformatics from Bharathidasan University, Trichy

Vigneshwaran Renganathan

Senior Research Fellow
name

Credentials


B.Sc in Biochemistry from Bharathidasan University, Trichy
M.Sc in Bioinformatics from Bharathidasan University, Trichy

Saladi Sreedivya

Junior Research Fellow
name

Credentials


B.Sc in Biotechnology from Andra University, Visakhapatnam
M.Sc in Biotechnology from Annamalai University, Chidambaram

Saravana Raja

Junior Research Fellow
name

Credentials


M.Tech in Bioinformatics from Bharathidasan University, Trichy