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MOLECULAR CHAPERONE LAB

Dept of Biochemistry, Indian Institute of Science, Bangalore.

Research Area

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What we do


Understanding how proteins accurately fold into three-dimensional structures in the cell is a central problem in modern biology. After ribosomal synthesis, the nascent polypeptides must actively fold into their native conformations to function properly within the cell. Protein misfolding leads to cellular accumulation of incorrectly folded proteins, which is the cause of many diseases including Alzheimer's, Huntington, Prion diseases, and Cancer. Ordered protein folding in the cellular cramped chaos is only possible under the supervision of specialized proteins, collectively referred as "Molecular Chaperones" which belong to Hsp70 and Hsp40/J-class. These highly conserved group of proteins recognize and stabilize partially folded intermediates of proteins during cellular processes such as protein translation, transport across organellar membranes, folding and degradation, as well as facilitating the refolding of proteins damaged after exposure of cells to stress.


The long-term goal of our research is to understand the intricate functional network of Hsp70 and Hsp40/J-class in the cytosol and different cell organelles. By utilizing yeast and mammalian model systems, my lab will investigate the cellular functions of molecular chaperones using a combination of experimental tools from genetics and cell biology with biochemistry and biophysics. We will address the role(s) of molecular chaperones in following different physiological functions.

-PDS Lab.

Milestones

Media Reports

Science Media IISc The Hindu Naie Dhuniya Bangalore Mirror TOI NDTV Gadget 01 Economictimes 01 TOI 02 Indian Express 01

Model Organisms

budding yeast E.coli yeast Human

Recent News


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Congrats Kondalarao B on successfully submitting his ‘PhD Thesis’ *****      Congrats Dr Devanjan Sinha on receving ‘INSA YOUNG SCIENTIST AWARD 2017’ *****      Congrats Shubhi Srivastava on successfully defending her ‘PhD Thesis’ *****      Congrats Kondalarao B on receiving ‘Young Scientist Award’ in Biology for the year 2015-2016 from Dr. K.V. Rao Scientific Society.     *****      Congrats Prasenjit Prasad Saha on being appointed as Post Doctoral Fellow at Dr. Stanely L Hazen's Lab, Cleveland Clinic, Cleveland, OH      *****      Congrats Devanjan Sinha on being appointed as Assistant Professor at Institute of Science, Banaras Hindu University      *****      Congrats Kondalarao B & Shubhi Srivastava for representing at Keystone Symposia – Mitochondrial Dynamics, Steamboat Springs, Colorado,USA. from 3-7th Apr2016, Orel Presentation      *****      Congrats Kondalarao B & Shubhi Srivastava for representing at Gordon Research Seminar: Oxygen radicals Held at Ventura, California, USA from 6-7th Feb2016, Orel Presentation      *****      Congrats Vinaya Vishwanathan on receiving DR. A. S. PERUMAL AWARD for the year 2015-16      *****      Congrats Prasenjit Prasad Saha on receiving ‘B.S. Narasingha Rao Best Poster Award’at the international conference '14th FAOBMB Congress & 84th Annual meeting of SBC (I)’ on 27th Nov-30th Nov 2015, at Hyderabad, India.     *****